Since the duration of action of most opioids exceeds that of naloxone hydrochloride and the suspected opioid overdose may occur outside of supervised medical. This product information is intended only for residents of the united states. Naloxone hydrochloride injection, usp narcan 04 mgml4 mg. Dbl naloxone hydrochloride injection usp 400 microgramsml solution for injection. Material may be irritating to the mucous membranes and upper respiratory tract. Skin protection if solution contact with unprotected skin is likely, use of impervious gloves is a prudent practice. Patel et al 2007 mechanisms of cardiac protection from ischemiareperfusion injury. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Eye protection eye protection is not required during expected product use conditions but may be warranted should a splash potential exist. Naloxone is contraindicated in patients with hypersensitivity to naloxone or to any components of the commercially available product. Other companies are charging thousands of dollars to set up accounts and give you access to their. Press releases feature stories mylan in the news covid19 news resources fact sheets investors leadership corporate governance latest news. Naloxone binds to opioid receptors in the cns in a competitive manner, reversing or inhibiting characteristic opioid effects, including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence. Injectable and intranasal branded2 injectable generic3.
Safety data sheet narcan naloxone hydrochloride nasal spray. Naloxone hcl injection, usp, 2mg2ml minijet prefilled syringe with 21 gauge and 1. Plasma naloxone levels were determined by ria over a period of 636 hr in three groups of neonates, 1 those given 35 microgram iv n 6, 2 those given 70 microgram iv n 6 and 3 those given 200 microgram im n 17 naloxone hcl within 1 min of birth. Hospira naloxone hydrochloride injection, usp, carpuject. Administer in accordance with the instructions for use. Naloxone hydrochloride drug information, professional. Naloxone is an opioid antagonist used to reverse narcotic overdose. Sigmaaldrich offers a number of naloxone hydrochloride dihydrate products. Medical license or doctors prescription required to purchase. Naloxone hydrochloride injection, usp, is a solution containing naloxone hydrochloride, a competitive antagonist of opioid receptors. Buprenorphine hcl and naloxone hcl dihydrate sublingual tablets contain buprenorphine hcl and naloxone hcl dihydrate at a ratio of 4. Naloxone hydrochloride is a hydrochloride resulting from the formal reaction of equimolar amounts of naloxone and hydrogen chloride. Assess patient for signs and symptoms of opioid withdrawal vomiting, restlessness, abdominal cramps, increased bp, and temperature.
Aloxi palonosetron hcl injection description aloxi palonosetron hydrochloride is an antiemetic and antinauseant agent. Selected citations for naloxone hydrochloride include. Learn about the reported side effects, related class drugs, and how these medications will affect your daily lifestyle. Chemical formula c19h21no4 hcl, naloxone hydrochloride. In these settings, consider use of an alternative, naloxone product which can be titrated to effect and, where applicable, dosed according to weight see use in specific populations 8. Naloxone hydrochloride crm safety data sheet section 2. Hcl component approximate percent by weight cas number rtecs number naloxone hydrochloride 0. Naloxone hydrochloride drugspharmaceuticals with ndc code.
Naloxone hydrochloride injection, usp synonyms 17allyl4,5 epoxy3,14dihydroxymorphinan6one hydrochloride 2. It differs from oxymorphone in that the methyl group on the nitrogen atom is replaced by an allyl group. And address 275 north field drive lake forest, illinois 60045 usa emergency telephone chemtrec. Naloxone hydrochloride is anhydrous or contains two molecules of water of hydration. Naloxone hydrochloride injection, usp narcan 04 mgml4. Safety data sheet section 1 identification of the substancemixture and the companyundertaking contact information general alkermes, inc. Naloxone hydrochloride injection, usp may be administered intravenously, intramuscularly, or subcutaneously. Naloxone may also be combined with an opioid in the same pill to decrease the risk of opioid misuse.
Hazard information carcinogen list substance iarc ntp osha naloxone hydrochloride not listed not listed not listed emergency overview naloxone hydrochloride injection is a solution containing naloxone hydrochloride, a competitive antagonist of opioid receptors. Learn about reported side effects, related medication class, and daily life interactions. Hazardous ingredients present at less than 1% may include sodium chloride. Buprenorphine is a partial agonist at the muopioid receptor and an antagonist at the kappaopioid receptor. After intravenous administration of 35 and 70 microgram of naloxone peak levels of. Safety data sheet narcan naloxone hydrochloride it works. Material safety data sheet of naloxone hydrochloride abmole. Naloxone hydrochloride, pentazocine hydrochloride oral tablet 0. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Safety data sheet narcan naloxone hydrochloride nasal spray sds revision date. Buprenorphine hcl and naloxone hcl dihydrate sublingual tablets.
May cause eye, skin, or respiratory system irritation. Chemical product and company information manufacturer name hospira, inc. Naloxone hcl nasal spray 4mg counteracts the lifethreatening effects of opioid overdose. For research use only, not for human or veterinary use. Since most accidental overdoses occur in a home setting, it was developed for first responders, as well as family, friends, and caregivers. Naloxone hydrochloride safety data sheet section 2. Naloxone hydrochloride, pentazocine hydrochloride oral tablet. Naloxone hydrochloride sodium chloride hydrochloric acid water for injection cas number 51481608 7647145 7647010 regd. Respiratory depression, opioid narcoticinduced treatment 01 04 05 24 25 naloxone is considered the drug of choice to reverse respiratory depression caused by opioid drugs, including those with mixed agonistantagonist activity such as buprenorphine although the effects of buprenorphine are especially resistant to reversal by. Product identifier product identity narcan naloxone hydrochloride nasal spray alternate names chemical formula c19h21no4 hcl 1. Special hazards arising from the substance or mixture hazardous decomposition. Considered a pure antagonist, naloxone has no analgesic activity. It is commonly used for decreased breathing in opioid overdose.
Dailymed naloxone hydrochloride injection, solution. Since most accidental overdoses occur in a home setting, it was developed for first responders. Relevant identified uses of the substance or mixture and uses advised against. In some states naloxone is available over the counter.
Safety data sheet according to 29cfr19101200 and ghs rev. Severity depends on dose of naloxone, the opioid in. Empirical formula hill notation c 19 h 21 no 4 hcl 2h 2 o. Naloxone decreases respiratory depression but also reversesanalgesia. Naloxone hydrochloride injection, usp medplus physician. Extinguishing media as with any fire, use extinguishing media appropriate for primary cause of fire 5. Citations are publications that use tocris products. Naloxone hydrochloride injection, usp respiratory protection respiratory protection is not needed during normal product use.
Jan, 2020 naloxone hydrochloride, usp is chemically designated 17allyl4,5. Narcan nasal spray counteracts the lifethreatening effects of an opioid overdose. Naloxone injection fda prescribing information, side. Naloxone hydrochloride, usp is chemically designated 17allyl4,5. Naloxone, an opioid antagonist, is a synthetic congener of oxymorphone. Hydrochloric acid sodium chloride mouse oral ld 50 4gkg skin irritation rabbit mild eye irritation rabbit mild rabbit dermal ld 50 10gkg rat oral ld 50 238277 mgkg naloxone hydrochloride revision date. Your new online msds binder is a place for you to store the material safety data sheets you need to. Multipledose solutions contain methylparaben and propylparaben which are added as. Dbl naloxone hydrochloride, solution for injection medsafe. Ensure that medical personnel are aware of the materials involved and take precautions to protect themselves.
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